Haemoglobin E in Burmese

Haemoglobin E-beta Thalassaemia in Singapore.

Medical History Twenty patients (36%) had a splenectomy. Fourteen (25%) patients had developed gallstones and 7 had a cholecystectomy performed. Other medical complications of disease and iron overload are summarised in Table 1. In addition, 21 out of the 55 patients had a MRI T2* of the heart and liver performed. None had iron loading in the heart. Twenty (98%) patients had evidence of iron lo...

Studies in haemoglobin E beta-thalassaemia.

Haemoglobin E beta-thalassaemia is the commonest form of severe thalassaemia in many Asian countries, but little is known about its natural history, the reasons for its clinical diversity, or its optimal management. Despite its frequency, haemoglobin E beta-thalassaemia is often managed in an ill-defined and haphazard way, usually by demand transfusion. We studied a cohort of Sri Lankan patient...

Increased erythrocyte superoxide dismutase activities in beta 0-thalassaemia/haemoglobin E and in haemoglobin H diseases.

Erythrocyte superoxide dismutase activities were measured in 45 subjects, 15 each of beta 0-thalassaemia/haemoglobin (Hb) E disease, Hb H disease, and normal. The erythrocyte superoxide dismutase activities were significantly higher in the patients with beta 0-thalassaemia/Hb E and Hb H diseases than in the normal subjects. The increase of erythrocyte superoxide dismutase activities is most lik...

Direct detection of haemoglobin E with MnlI.

Homozygous haemoglobin E in association with hereditary ovalocytosis.

Hereditary stomatocytic ovalocytosis and haemoglobin E are two genes present in 3-5% of Malays. This is a report of a 22 year old Malay college student with homozygous haemoglobin E and hereditary stomatocytic ovalocytosis where the clinical effects seen were the result of the summation of these genes: he was asymptomatic, presenting with moderate jaundice, moderate hepatosplenomegaly, and a mi...